Dry extract.
English name : Salacia
Family : Hippocrateaceae
Part used : Roots
Traditional uses1-3: The roots are acrid, bitter, thermogenic, urinary, astringent, anodyne, anti-inflammatory. They are useful in vitiated conditions of vata, diabetes, haemorrhoids, rheumatism, gonorrhoea and skin diseases.
Phytochemistry14-20: The major bioactive constituents of Salacia reticulata are a xanthone-e-glucoside, mangiferin and two compounds with unique thiosugar sulfonium sulfate structures viz., salacinol and kotalanol. The other conistuents of Salacia reticulata include polyphenols viz,. epicatechin, (epigallocatechin, methylepigallocatechin etc; triterpenoids viz., kotalagenin 16-acetate, 26-hydroxy-1,3-fridelanedione, maytenfolic acid, dihydroxyolean-12-en-29-oie acid etc,.
Pharmacology4-13: Salacia reticulata has been reported to possess potent anti-diabetic activity in animal models. A major part of the anti-diabetic activity is attributed to the inhibition of glucosidase by the constituents of the extract in the small intestine. In addition, other mechanisms such as increased insulin sensitivity, aldose reductase inhibition etc., are also exhibited by components of Salacia reticulata. The plant is also reported to possess anti-obesity, hypolipidemic, hepatoprotective and anti-oxidant properties.
Main use: anti-diabetic.
Reference:
1. Indian Medicinal plants- a compendium of 500 species, Pub: Orient longman Ltd., Hyderabad, 1996, 5, 47.
2. Husain A, Virmani O.P et al, Dictionary of Indian Medicinal plants, Pub: Central Institute of Medicinal and Aromatic plants, Lucknow, 1992, 400
3. Nadkarni K. M., The Indian Materia Medica Pub:Popular prakashan Pvt. Ltd., Bombay, 1993; 1 : 1089.
4. Serasinghe S., Serasinghe P.,Yamazaki H., Nishiguchi K., et al, Oral hypoglycemic effect of Salacia reticulata in the streptozotocin induced diabetic rat, Phytotherapy Res. 1990,4, 205-206.
5. Yoshikawa M., Murakami T., Shimada H., Matsuda H., et al, Salicinol, Potent Antidiabetic Principle with Unique Thiosugar Sulfonium Sulfate Structure from the Ayurvedic Traditional Medicine Salacia reticulata in Sri Lanka and India, Tetrahedron Letters, 1997, 38(48), 8367-8370.
6. Yoshikawa M., Nishida N., Shimoda H., Takada M., et al, Polyphenol constituents from Salacia species: quantitative analysis of mangiferin with alpha-glucosidase and aldose reductase inhibitory activities, Yakugaku Zasshi, 2001, 121(5), 371-378.
Note: The extract is also available for Salacia Oblonga/Salacia Reticulata
2)Residual pesticide analysis is performed only on request.
